Auflistung nach Schlagwort "570 - Biowissenschaften, Biologie"

Gerade angezeigt 1 - 20 von 39

Biologie: Mit Sherlock Holmes, CSI & Co. auf Entdeckungsreise
(Hessische Heimvolkshochschule Burg Fürsteneck, 2014) Kremer, Kerstin; Arnold, Julia
04B - Beitrag Konferenzschrift
Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
(Mary Ann Liebert, 2013) de Wild, Michael; Schumacher, Ralf; Kyrill, Maier; Schkommodau, Erik; Thoma, Daniel; Bredell, Marius; Kruse, Astrid; Grätz, Klaus; Weber, Franz
The treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants that are designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor-loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created on autograft harvesting. The aim of this study was to determine the mechanical properties and potential of bone formation of light weight implants generated by selective laser melting (SLM). We mainly focused on osteoconduction, as this is a key feature in bone healing and could serve as a back-up for osteoinduction and cell transplantation strategies. To that end, defined implants were produced by SLM, and their surfaces were left untreated, sandblasted, or sandblasted/acid etched. In vivo bone formation with the different implants was tested throughout calvarial defects in rabbits and compared with untreated defects. Analysis by micro computed tomography (µCT) and histomorphometry revealed that all generatively produced porous Ti structures were well osseointegrated into the surrounding bone. The histomorphometric analysis revealed that bone formation was significantly increased in all implant-treated groups compared with untreated defects and significantly increased in sand blasted implants compared with untreated ones. Bone bridging was significantly increased in sand blasted acid-etched scaffolds. Therefore, scaffolds manufactured by SLM should be surface treated. Bone augmentation beyond the original bone margins was only seen in implant-treated defects, indicating an osteoconductive potential of the implants that could be utilized clinically for bone augmentation purposes. Therefore, designed porous, lightweight structures have potential for bone regeneration and augmentation purposes, especially when complex and patient-specific geometries are essential.
01A - Beitrag in wissenschaftlicher Zeitschrift
Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on rainbow trout liver cells are modulated by antioxidants
(Springer, 05.07.2014) Pietsch, Constanze; Hollender, Juliane; Burkhardt-Holm, Patricia; Dorusch, Falk
Abstract The world-wide distribution and high bioaccumulation potential of pentachlorophenol (PCP) in aquatic organisms imply a high toxicological impact in aquatic systems. Firstly, our investigations show that, similar to mammalian cell lines, PCP can be metabolized to tetrachlorohydroquinone (TCHQ) in the permanent cell line derived from rainbow trout liver cells (RTL W-1). Moreover, we demonstrate that PCP as well as its metabolite TCHQ is capable of influencing the viability of these cells. Three cell viability assays were performed to assess possible cellular targets of these substances. Thus, the toxicity of the PCP-derivative TCHQ was shown for the first time in a fish cell line. Further investigations revealed the involvement of ROS in the cytotoxicity of PCP and its metabolite TCHQ. The observation of oxidative stress due to PCP or TCHQ exposure does provide a plausible explanation for the increased cytotoxicity of higher concentrations of both substances and implies possible mechanisms underlying these observations. In addition, antioxidants such as ascorbic acid and quercetin modulate the detrimental effects of PCP and TCHQ whereby both compounds exacerbate the cytotoxic effects of high PCP and TCHQ concentrations.
01A - Beitrag in wissenschaftlicher Zeitschrift
Der Beitrag des Biologieunterrichts zum Thema Gesundheit -Ergebnisse des Round-Table-Gesprächs "Gesundheitsbildung - quo vadis!?"
(StudienVerlag, 2019) Arnold, Julia; Schwanewedel, Julia; Schaal, Steffen; Kattmann, Ulrich; Hammann, Marcus; Lindner, Martin
04B - Beitrag Konferenzschrift
Der neue Arbeitskreis Gesundheit und Biologie im VBIO stellt sich vor
(Verband Biologie, Biowissenschaften und Biomedizin in Deutschland, 2019) Arnold, Julia; Dannemann, Sarah; Gropengießer, Ilka; Heuckmann, Benedikt; Kahl, Lea; Schaal, Sonja; Schaal, Steffen; Schlüter, Kirsten; Schwanewedel, Julia; Simon, Uwe; Spörhase, Ulrike
01A - Beitrag in wissenschaftlicher Zeitschrift
Die Farbe der Geckos: Eine Didaktische Rekonstruktion des evolutionsbiologischen Konzepts der Anpassung
(2016) Arnold, Julia; Kremer, Kerstin
01A - Beitrag in wissenschaftlicher Zeitschrift
Die Gänse des Konrad Lorenz
(2012) Arnold, Julia; Kremer, Kerstin
01B - Beitrag in Magazin oder Zeitung
DigiLaB: Digitale Medien in der Lehramtsausbildung Biologie
(17.09.2018) Mahler, Daniela; Arnold, Julia
06 - Präsentation
Dynemicin analogs: Syntheses, methods of preparation and use
(United States Patent and Trademark Office, 04.01.1994) Smith, Adrian L.; Hwang, Chan-Kou; Wendeborn, Sebastian; Nicolaou, Kyriacos C.; Schreiner, Erwin P.; Stahl, Wilhelm; Dai, Wei-Min; Maligres, Peter E.; Suzuki, Toshio
A fused ring system compound is disclosed that contains an epoxide group on one side or the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bounded to (i) a sugar moiety as the ogligosaccharide portion or(ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods or preparing a compound.
12 - Patent
Enantiomeric dynemicin analogs, preparation and use thereof
(World Intellectual Property Organization, 25.11.1993) Smith, Adrian L.; Wendeborn, Sebastian; Nicolaou, Kyriacos; Schreiner, Erwin P.; Dai, Wei-Min; Susuki, Toshio
An enantiomer of a fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The enantiomeric compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties that are enhanced over their racemates. Chimeric compounds having the enantiomeric fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing an enatiomeric compound or an enantiomeric chimer are disclosed, as are methods of preparing an enantiomeric compound.
12 - Patent
Environmental chemicals affect circadian rhythms. An underexplored effect influencing health and fitness in animals and humans
(Elsevier, 04/2021) Zheng, Xuehan; Zhang, Kun; Zhao, Yanbin; Fent, Karl
Circadian rhythms control the life of virtually all organisms. They regulate numerous aspects ranging from cellular processes to reproduction and behavior. Besides the light-dark cycle, there are additional environmental factors that regulate the circadian rhythms in animals as well as humans. Here, we outline the circadian rhythm system and considers zebrafish (Danio rerio) as a representative vertebrate organism. We characterize multiple physiological processes, which are affected by circadian rhythm disrupting compounds (circadian disrupters). We focus on and summarize 40 natural and anthropogenic environmental circadian disrupters in fish. They can be divided into six major categories: steroid hormones, metals, pesticides and biocides, polychlorinated biphenyls, neuroactive drugs and other compounds such as cyanobacterial toxins and bisphenol A. Steroid hormones as well as metals are most studied. Especially for progestins and glucocorticoids, circadian dysregulation was demonstrated in zebrafish on the molecular and physiological level, which comprise mainly behavioral alterations. Our review summarizes the current state of knowledge on circadian disrupters, highlights their risks to fish and identifies knowledge gaps in animals and humans. While most studies focus on transcriptional and behavioral alterations, additional effects and consequences are underexplored. Forthcoming studies should explore, which additional environmental circadian disrupters exist. They should clarify the underlying molecular mechanisms and aim to better understand the consequences for physiological processes.
01A - Beitrag in wissenschaftlicher Zeitschrift
Essen für das Erbgut
(2014) Arnold, Julia; Kircher, Sarah
01B - Beitrag in Magazin oder Zeitung
Fleisch der Zukunft? Oder: Wie Fleisch aus der Petrischale Welthungerprobleme lösen soll
(2018) Mahler, Daniela; Arnold, Julia
01B - Beitrag in Magazin oder Zeitung
Fleisch is(s)t mein Gemüse - Ein theoretisches Strukturmodell zum nachhaltigkeitsorientierten Konsumhandeln im Ernährungsbereich
(01.03.2018) Bauer, Deidre; Arnold, Julia; Kremer, Kerstin
06 - Präsentation
Forensische Methoden mit Haut und Haar
(2014) Arnold, Julia; Kremer, Kerstin
99 - Sonstiges
Forschendes Lernen in der Biologie
(Springer, 2017) Bruckermann, Till; Arnold, Julia; Kremer, Kerstin; Schlüter, Kirsten; Bruckermann, Till; Schlüter, Kirsten
04A - Beitrag Sammelband
Heute handeln für die Zukunft – Was kannst du tun? Ideen für ein nachhaltiges Leben
(2018) Mahler, Daniela; Arnold, Julia
01B - Beitrag in Magazin oder Zeitung
Hilfe für Kannenpflanzen
(Cornelsen, 2013) Arnold, Julia; Kremer, Kerstin; Schmiemann, Philipp; Mayer, Jürgen
04A - Beitrag Sammelband
Humanoide Kybernetik - Der Mensch als Kraftwerk
(Hogrefe, 2019) Goetze, Max; Schulte, Volker; Schulte, Volker; Verkuil, Arie Hans
Der Beitrag beschreibt die Möglichkeit, Abwärme des menschlichen Körpers energetisch zu nutzen. Im Artikel werden unterschiedliche Praxisbeispiele gezeigt, wie menschliche körperliche Abwärme absorbiert und genutzt wird.
04A - Beitrag Sammelband
Intelligente Trocknung