Listen
2 Ergebnisse
Ergebnisse nach Hochschule und Institut
Publikation How technical innovations may help to prevent drug shortages in switzerland(Schweizerische Chemische Gesellschaft, 2023) Gygax, Daniel; Eigenmann, Kaspar; Suter, Christian; Hürzeler Müller, Marianne; Mahmoud, Ahmed; Mosbacher, Johannes; Pöllinger, NorbertIn this work, we investigated the technical feasibility of 'on-demand' production of selected drugs to cover their demand for a time window of 90 days. We focused on two sub-processes 'automated chemical synthesis' and 'formulation in micropellets' to enable personalized dosing. The production of drugs 'on-demand' is challenging, important, but also attractive. Switzerland could thus gain access to an additional instrument for increasing resilience for supply-critical drugs. The biggest challenge in the case study presented here is the scalability of automated chemical synthesis and the application range of micropellet formulations.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Isolation and characterization of pancreatic lipase inhibitor from rapeseed seeds(Oles Honchar Dnipro National University, 2023) Krusir, Galyna; Pylypenko, Liudmyla; Sevastyanova, Elena; Mazurenko, Kseniia; Moshtakov, Serhii; Shunko, Hanna; Vitiuk, Antonina; Shpyrko, Tetyana; Zdoryk, OleksandrDigestive enzymes and inhibitors of digestive enzymes are effective correctors of digestive processes in the body, the violation of which leads to various diseases (diabetes, hyperlipidemia, cardiovascular diseases, neoplasms and others). The present study identified the most promising plant objects characterized by the highest antilipolytic activity (ALA) in relation to pancreatic lipase. The experimental results indicate that the inhibitory activity (IA) of phenolic compounds of rapeseed is so much high and comparable to ALA "Orlistat", reaching 95.5 % of its activity. This determines the potential possibility of using the phenolic complex of rapeseed as an alternative to anti-lipolytic drugs of synthetic origin. The predominant component of the phenolic complex is low molecular weight phenolic compounds; polyphenolic compounds are almost equally represented by tannins – condensed and hydrolyzable. According to TLC data, the main components of low molecular weight phenols are glucopyranosylsinapate, sinapic acid and sinapin. Among the phenolic compounds of rapeseed seeds, sinapine and hydrolyzable tannins have the highest anti lipolytic activity against lipase. Significant ability to inhibit the action of pancreatic lipase is characterized by both low molecular weight and high molecular weight phenolic compounds of rapeseed.01A - Beitrag in wissenschaftlicher Zeitschrift