Institut für Medizintechnik und Medizininformatik
Dauerhafte URI für die Sammlunghttps://irf.fhnw.ch/handle/11654/23
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Ergebnisse nach Hochschule und Institut
Publikation Interferometric label-free biomolecular detection system(IOP Publishing Ltd, 2006) Hradetzky, David; Mueller, Claas; Reinecke, HolgerThis work presents a simple evanescent wave sensing system based on an interferometric approach, suitable to meet the requirements of label-free sensor systems for detecting biomolecular interactions. It represents a basic concept towards label-free detection systems in various applications. The basic objectives of transducers for evanescent wave sensing are discussed. An optical detection system based on a interferometric approach using Young's double slit configuration is discussed, set-up and characterized. With refractometric measurements of various sucrose dilutions, the performance of the pure optical set-up is evaluated.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Interferometric sensor platform for biomolecular interaction analysis(VDE, 2005) Hradetzky, David; Müller, Claas; Reinecke, Holger04B - Beitrag KonferenzschriftPublikation Label free detection of biomolecular interactions(IEEE, 2005) Hradetzky, David; Müller, Claas; Reinecke, HolgerThis work presents a simple evanescent wave sensing system based on an interferometric approach suitable to meet the demands on label free sensor systems for the detection of biomolecular interactions especially. It is representing a basic concept towards high throughput application. The system performance and reproducibility was evaluated with refractometric measurements of sucrose dilutions. A mean resolution of the effective refractive index of 3sigma(Deltamacrnmacr eff )=0.9middot10 -6 without averaging and a reproducibility below sigma r =0.1middot10 -6 were achieved. The suitability for the detection of biomolecular interactions was validated with the detection of a DNA hybridization04B - Beitrag Konferenzschrift