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Ergebnisse nach Hochschule und Institut
Publikation Synthesis of typical sulfonamide antibiotics with [14C]- and [13C]-labeling on the phenyl ring for use in environmental studies(Springer, 08.03.2022) Wu, Xuan; Yao, Yao; Wang, Lianhong; Zhou, Dashun; Sun, Feifei; Chen, Jianqiu; Ji, Rong; Corvini, PhilippeBackground Due to their widespread use, sulfonamide antibiotics (SAs) have become ubiquitous environmental contaminants and thus a cause of public concern. However, a complete understanding of the behavior of these pollutants in complex environmental systems has been hampered by the unavailability and high cost of isotopically labeled SAs. Results Using commercially available uniformly [14C]- and [13C]-labeled aniline as starting materials, we synthesized [phenyl-ring-14C]- and [phenyl-ring-13C]-labeled sulfamethoxazole (SMX), sulfamonomethoxine (SMM), and sulfadiazine (SDZ) in four-step (via the condensation of labeled N-acetylsulfanilyl chloride and aminoheterocycles) or five-step (via the condensation of labeled N-acetylsulfonamide and chloroheterocycles) reactions, with good yields (5.0–22.5% and 28.1–54.1% for [14C]- and [13C]-labeled SAs, respectively) and high purities (> 98.0%). Conclusion The synthesis of [14C]-labeled SAs in milligram amounts enables the preparation of labeled SAs with high specific radioactivity. The efficient and feasible methods described herein can be applied to the production of a variety of [14C]- or [13C]-labeled SAs for studies on their environmental behavior, including the fate, transformation, and bioaccumulation of these antibiotics in soils and aqueous systems.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Insights into the applications of 3D bioprinting for bioremediation technologies(Elsevier, 2021) Ke, Zhuang; Obamwonyi, Osagie; Kolvenbach, Boris; Ji, Rong; Liu, Shuangjiang; Jiang, Jiandong; Corvini, PhilippeA plethora of organic pollutants such as pesticides, polycyclic and halogenated aromatic hydrocarbons, and emerging pollutants, such as flame retardants, is continuously being released into the environment. This poses a huge threat to the society in terms of environmental pollution, agricultural product quality, and general safety. Therefore, effective removal of organic pollutants from the environment has become an important challenge to be addressed. As a consequence of the recent and rapid developments in additive manufacturing, 3D bioprinting technology is playing an important role in the pharmaceutical industry. At the same time, an increasing number of microorganisms suitable for the production of biomaterials with complex structures and functions using 3D bioprinting technology, have been identified. This article briefly discusses the principles, advantages, and disadvantages of different 3D bioprinting technologies for pollutant removal. Furthermore, the feasibility and challenges of developing bioremediation technologies based on 3D bioprinting have also been discussed01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Long-term field study on fate, transformation, and vertical transport of tetrabromobisphenol A in soil–plant systems(American Chemical Society, 21.03.2021) Corvini, Philippe; Songfeng, Wang; Xuan, Wu; Rong, Guo; Wang, Qilin; Guo, Hongyan; Sun, Feifei; Ji, RongSoil contamination with tetrabromobisphenol A (TBBPA) has been an environmental concern for many years, but in situ studies of the fate and potential risk of TBBPA are lacking. In this study, we investigated the dissipation, metabolism, strong alkali-hydrolytic (SAH-TBBPA), and vertical movement of TBBPA in the field with and without rice-wheat rotation and reed growth for 1225 days. After 342 days of incubation, 21.3% of the TBBPA remained in the surface soil accompanied by obvious leaching to deeper soil layers in the first 92 days. By day 1225, TBBPA was nearly absent from the surface soil layer. A very low amount of SAH-TBBPA (2.31–3.43 mg/kg) was detected during the first 342 days of incubation. In the surface soil, five metabolites were identified that represented four interconnected pathways: oxidative skeletal cleavage, O-methylation, type II ipso-substitution, and reductive debromination. Both rice–wheat rotation and monocultural reed growth accelerated TBBPA removal in the field by stimulating the anaerobic debromination and aerobic O-methylation, especially the oxidative skeletal cleavage of TBBPA in the rhizosphere soil. Though far from comprehensive, our study investigated the natural attenuation and metabolism of TBBPA in situ and the influence by crops to estimate the environmental risk of TBBPA in a field scale.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Enhanced Transformation of Tetrabromobisphenol A by Nitrifiers in Nitrifying Activated Sludge(American Chemical Society, 2015) Li, Fangjie; Jiang, Bingqi; Nastold, Peter; Kolvenbach, Boris; Chen, Jianqiu; Wang, Lianhong; Guo, Hongyan; Corvini, Philippe; Ji, Rong01A - Beitrag in wissenschaftlicher Zeitschrift