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Self-Assembling Peptide Matrix for treatment of dentin hypersensitivity: A randomized controlled clinical tria
(American Academy of Periodontology, 03/2018) Schlee, Markus; Rathe, Florian; Bommer, Claudine; Kind, Lucy
Patient-reported dentin hypersensitivity [DHS] pain is a common finding linked with periodontal disease. This pilot clinical study investigates a novel therapeutic regimen using self-assembling peptide matrix [SAPM] gel (test) compared with use of an 8% arginine and calcium carbonate [ACC] toothpaste (control) for treatment of DHS.
01A - Beitrag in wissenschaftlicher Zeitschrift
Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide
(SAGE, 27.03.2017) Kind, Lucy; Stevanovic, Sabrina; Wuttig, Sina; Wimberger, Sandra; Hofer, Joëlle; Müller, Bert; Pieles, Uwe
Self-assembling β-sheet forming peptide P11-4 has shown potential in the treatment and prevention of dental caries by supporting tissue regeneration. It has previously been shown that application of monomeric P11-4 solution to early carious lesions can increase net mineral gain by forming de novo hydroxyapatite crystals. The hypothesis for the mode of action was that monomeric self-assembling peptide P11-4 diffuses into the subsurface lesion body and assembles therein into higher order fibrils, facilitating mineralization of the subsurface volume by mimicking the natural biomineralization of the tooth enamel.
01A - Beitrag in wissenschaftlicher Zeitschrift