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Publikation Absorption and metabolism of the natural sweeteners erythritol and xylitol in humans. A dose-ranging study(MDPI, 30.08.2022) Wölnerhanssen, Bettina K.; Meyer-Gerspach, Anne Christin; Bordier, Valentine; Teysseire, Valentine; Senner, Frank; Schlotterbeck, Götz; Drewe, Jürgen; Beglinger, ChristophThe natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity(MDPI, 05.11.2021) Bordier, Valentine; Teysseire, Fabienne; Schlotterbeck, Götz; Beglinger, Christoph; Meyer-Gerspach, Anne-Christin; Wölnerhanssen, Bettina; Senner, FrankIn patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in- gestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3-Ortho-methyl-glucose (3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentra- tion was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol, or erythritol), nor the time-by-group interaction effects were significant (p = 0.829, p = 0.821, and p = 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity01A - Beitrag in wissenschaftlicher Zeitschrift