de Wild, Michael
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de Wild, Michael
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- PublikationNovel microcalorimetric assay for antibacterial activity of implant coatings. The cases of silver‐doped hydroxyapatite and calcium hydroxide(Wiley, 08/2015) Braissant, Olivier; Chavanne, Philippe; de Wild, Michael; Pieles, Uwe; Stevanovic, Sabrina; Schumacher, Ralf; Straumann, Lukas; Wirz, Dieter; Gruner, Philipp; Bachmann, Alexander; Bonkat, Gernot [in: Journal of Biomedical Materials Research Part B: Applied Biomaterials]Biomaterials with antimicrobial properties are now commonly used in different clinical specialties including orthopedics, endodontic, and traumatology. As a result, assessing the antimicrobial effect of coatings applied on implants is of critical importance. In this study, we demonstrate that isothermal microcalorimetry (IMC) can be used for monitoring bacterial growth and biofilm formation at the surface of such coatings and for determining their antimicrobial effects. The antibacterial effects of silver doped hydroxyapatite (HA) and calcium hydroxide coatings on Staphylococcus epidermidis were determined with a minimal workload. Using the Gompertz growth model we determined biofilm growth rates close to those values reported in the literature. Furthermore, we were able to estimate the reduction in the bacterial inocula originally applied at the surface of the coatings. Therefore, in addition to monitoring the antimicrobial effect of silver doped HA and calcium hydroxide coatings, we also demonstrate that IMC might be a valuable tool for assessing such antimicrobial properties of implant coatings at a minimal workload.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationInvestigation of structural resorption behavior of biphasic bioceramics with help of gravimetry, μCT, SEM, and XRD(07.05.2015) de Wild, Michael; Molenberg, Aart; Amacher, Fabienne; Chris, Bradbury [in: Journal of Biomedical Materials Research. Part B: Applied Biomaterials]Resorbable bone substitute materials are widely used for bone augmentation after tumor resection, parallel to implant placement, or in critical size bone defects. In this study, the structural dissolution of a biphasic calcium phosphate bone substitute material with a hydroxyapatite (HA)/tricalcium phosphate (ß-TCP) ratio of 60/40 was investigated by repeatedly placing porous blocks in EDTA solution at 37°C. At several time points, the blocks were investigated by SEM, µCT, and gravimetry. It was found that always complete 2–3 µm sized grains were removed from the structure and that the ß-TCP is dissolved more rapidly. This selective dissolution of the ß-TCP grains was confirmed by XRD measurements. The blocks were eroded from the outside toward the center. The structure remained mechanically stable because the central part showed a delayed degradation and because the slower dissolving HA grains preserved the integrity of the structure.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationN-methyl Pyrrolidone/Bone Morphogenetic Protein-2 Double Delivery with In Situ Forming Implants(Elsevier, 04/2015) Karfeld-Sulzer, Lindsay S.; Ghayor, Chafik; de Wild, Michael [in: Journal of Controlled Release]01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationSINAPIS – Slurry Injection of Nano-scale Particles into Implant Surfaces(2015) Schumacher, Ralf; Rohner, A.M.; Melzner, Alexander; de Wild, Michael06 - Präsentation
- PublikationNovel perfused compression bioreactor system as an in vitro model to investigate fracture healing(Frontiers, 2015) de Wild, Michael; Hoffmann, Waldemar; Feliciano, Sandra; Martin, Ivan; Wendt, David [in: Frontiers in Bioengineering and Biotechnology]Secondary bone fracture healing is a physiological process that leads to functional tissue regeneration via endochondral bone formation. In vivo studies have demonstrated that early mobilization and the application of mechanical loads enhances the process of fracture healing. However, the influence of specific mechanical stimuli and particular effects during specific phases of fracture healing remain to be elucidated. In this work, we have developed and provided proof-of-concept of an in vitro human organotypic model of physiological loading of a cartilage callus, based on a novel perfused compression bioreactor (PCB) system. We then used the fracture callus model to investigate the regulatory role of dynamic mechanical loading. Our findings provide a proof-of-principle that dynamic mechanical loading applied by the PCB can enhance the maturation process of mesenchymal stromal cells toward late hypertrophic chondrocytes and the mineralization of the deposited extracellular matrix. The PCB provides a promising tool to study fracture healing and for the in vitro assessment of alternative fracture treatments based on engineered tissue grafts or pharmaceutical compounds, allowing for the reduction of animal experiments.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationImprovement of mechanical properties of 3D printed hydroxyapatite scaffolds by culture of osteoblast-like cells under perfusion flow(2015) Hugot Beaufils, Marina; Chavanne, Philippe; Rimmer, Natalie; Burgio, Floriana; Rohner, Adrian; Schumacher, Ralf; de Wild, Michael; Martin, Yvan; Pieles, Uwe; Zimmermann, Simon; Papadimitropoulos, Adam [in: European Cells and Materials]04 - Beitrag Sammelband oder Konferenzschrift
- PublikationNANTI: Development of a Nanoporous Antibacterial Surface for Titanium Implants by Electrochemical Copper deposition(2015) de Wild, Michael; Jung, Christiane06 - Präsentation
- PublikationStiffness - anisotropy of porous implant geometries(2015) de Wild, Michael; Schumacher, Ralf; Rüegg, Jasmine; Zimmermann, Simon; Weber, Franz E. [in: eCM Congress XVI]04 - Beitrag Sammelband oder Konferenzschrift
- PublikationMonitoring Ultraschallparameter im Reinigungsbad: SonoCheck Dosimeter versus Kavitationsrauschpegel(2015) de Wild, Michael; Jung, Christiane; Zwahlen, Alexander06 - Präsentation
- PublikationPorous shape-memory-scaffolds as mechanically active bone implants(2015) de Wild, Michael; Hoffmann, Waldemar; Schlottig, Falko; Schumacher, Ralf; Bormann, Therese; Martin, Ivan; Müller, Bert; Mürrle, Ulrich06 - Präsentation