Reduced exposure to PM10 and attenuated age-related decline in lung function
Vorschaubild nicht verfügbar
Autor:innen
Downs, Sara H.
Schindler, Christian
Liu, L.-J. Sally
Keidel, Dirk
Brutsche, Martin H.
Gerbase, Margaret W.
Keller, Roland
Künzli, Nino
Leuenberger, Philippe
Autor:in (Körperschaft)
Publikationsdatum
2007
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
New England Journal of Medicine
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
357
Ausgabe / Nummer
23
Seiten / Dauer
2338-2347
Patentnummer
Verlag / Herausgebende Institution
Massachusetts Medical Society
Verlagsort / Veranstaltungsort
Waltham
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Background:
Air pollution has been associated with impaired health, including reduced lung function in adults. Moving to cleaner areas has been shown to attenuate adverse effects of air pollution on lung function in children but not in adults.
Methods:
We conducted a prospective study of 9651 adults (18 to 60 years of age) randomly selected from population registries in 1990 and assessed in 1991, with 8047 participants reassessed in 2002. There was complete information on lung volumes and flows (e.g., forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1], FEV1 as a percentage of FVC, and forced expiratory flow between 25 and 75% of the FVC [FEF25–75]), smoking habits, and spatially resolved concentrations of particulate matter that was less than 10 μm in aerodynamic diameter (PM10) from a validated dispersion model assigned to residential addresses for 4742 participants at both the 1991 and the 2002 assessments and in the intervening years.
Results:
Overall exposure to individual home outdoor PM10 declined over the 11-year follow-up period (median, −5.3 μg per cubic meter; interquartile range, −7.5 to −4.2). In mixed-model regression analyses, with adjustment for confounders, PM10 concentrations at baseline, and clustering within areas, there were significant negative associations between the decrease in PM10 and the rate of decline in FEV1 (P=0.045), FEV1 as a percentage of FVC (P=0.02), and FEF25–75 (P=0.001). The net effect of a decline of 10 μg of PM10 per cubic meter over an 11-year period was to reduce the annual rate of decline in FEV1 by 9% and of FEF25–75 by 16%. Cumulative exposure in the interval between the two examinations showed similar associations.
Conclusions:
Decreasing exposure to airborne particulates appears to attenuate the decline in lung function related to exposure to PM10. The effects are greater in tests reflecting small-airway function.
Schlagwörter
Fachgebiet (DDC)
610 - Medizin und Gesundheit
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
0028-4793
1533-4406
1533-4406
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Nein
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Closed
Lizenz
Zitation
DOWNS, Sara H., Christian SCHINDLER, L.-J. Sally LIU, Dirk KEIDEL, Lucy BAYER-OGLESBY, Martin H. BRUTSCHE, Margaret W. GERBASE, Roland KELLER, Nino KÜNZLI, Philippe LEUENBERGER, Nicole M. PROBST-HENSCH, Jean-Marie TSCHOPP, Jean-Pierre ZELLWEGER, Thierry ROCHAT, Joel SCHWARTZ und Ursula ACKERMANN-LIEBRICH, 2007. Reduced exposure to PM10 and attenuated age-related decline in lung function. New England Journal of Medicine. 2007. Bd. 357, Nr. 23, S. 2338–2347. DOI 10.1056/nejmoa073625. Verfügbar unter: https://irf.fhnw.ch/handle/11654/45632