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19 Ergebnisse
Bereich: Suchergebnisse
Publikation Scaling down the heat transfer in multipurpose plants(26.06.2024) Zogg, Andreas04B - Beitrag KonferenzschriftPublikation Kontinuierliche Ethoxylierung(25.04.2024) Zogg, Andreas; Zahnd, This; Brönnimann, BenediktModellbasiertes Sicherheitskonzept für die Entwicklung einer kontinuierlichen Ethoxylierung. Modellvalidierung mittels kontinuierlichem Kalorimeter innerhalb einer Glove-Box.06 - PräsentationPublikation Modeling-based approach towards quality by design for a telescoped process(Schweizerische Chemische Gesellschaft, 2024) Zahnd, This; Kandziora, Maja; Levis, Michael K.; Zogg, AndreasA telescoped, two-step synthesis was investigated by applying Quality by Design principles. A kinetic model consisting of 12 individual reactions was successfully established to describe the synthesis and side reactions. The resulting model predicts the effects of changes in process parameters on total yield and quality. Contour plots were created by varying process parameters and displaying the model predicted process response. The areas in which the process response fulfils predetermined quality requirements are called design spaces. New ranges for process parameters were explored within these design spaces. New conditions were found that increased the robustness of the process and allowed for a considerable reduction of the used amounts of a reagent. Further optimizations, based on the newly generated knowledge, are expected. Improvements can either be direct process improvements or enhancements to control strategies. The developed strategies can also be applied to other processes, enhancing upcoming and preexisting research and development efforts.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Development of a novel measurement setup to study and predict electrostatic discharges in agitated glass‐lined vessels(Wiley, 12.02.2024) Brönnimann, Benedikt; Egli‐Tedesco, Daniel; Schwenzfeuer, Klaus; Zogg, AndreasTwo glass lined reactors in a launch platform facility operated by Syngenta have been damaged during the crystallization of an organic compound due to electrostatic discharges. The goal of this work was to design and commission a novel setup to measure charges and currents generated by this slurry in a laboratory‐scale reactor. An improved and more sophisticated setup was then proposed for possible implementation in Syngenta's own laboratories. With this novel setup, the electrostatic charging of stirred suspensions involving nonconductive solvents could be accurately measured in the context of a case study that involved the suspension that led to liner damages in the production facilities of Syngenta.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation New scale-up technologies for multipurpose pharmaceutical production plants. Use case of a heterogeneous hydrogenation process(American Chemical Society, 06.07.2023) Furrer, Thierry; Levis, Michael; Berger, Bernhard; Kandziora, Maja; Zogg, Andreas01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Die Chemie Pilotanlage der FHNW Muttenz(25.04.2023) Zogg, Andreas; Asprion, JonasDer Verein Miniplant 4.0 entwickelt im Process Technology Center an der FHNW neuartige Chemie-Pilotanlagen im Miniplant-Massstab. Der zentrale Scale-Down-Reaktor dient der präzisen Prozessentwicklung im Rührkessel. Insbesondere werden darin die lokalen thermischen Verhältnisse des Produktionsreaktors durch den Einsatz eines speziell designten Wärmetauschers exakt nachgebildet. Damit wird den Studenten und lokalen Unternehmen ein neuartiges Entwicklungswerkzeug zur Verfügung gestellt, welches einen schnelleren und präziseren Scale-Up von Produktionsverfahren direkt aus dem Labormassstab in den Produktionsreaktor erlaubt. Herr Prof. Dr. Andreas Zogg von der FHNW in Muttenz zeigt Ihnen den aktuellen Status der Anlage und die vielseitigen Schulungs- und Forschungsmöglichkeiten. Unterstützt wird er durch Herrn Dr. Jonas Asprion von der Firma Tool-Temp AG, welche die Kommerzialisierung der Temperierlösungen für Reaktormantel und Wärmetauscher anstrebt.06 - PräsentationPublikation New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants(Schweizerische Chemische Gesellschaft, 2021) Furrer, Thierry; Müller, Benedikt; Hasler, Christoph; Berger, Bernhard; Levis, Michael Karl; Zogg, AndreasThe classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Modeling-Based Approach Towards Quality by Design for a Telescoped Process(Hochschule für Life Sciences FHNW, 2022) Zogg, Andreas; Zahnd, This; Zogg, Andreas; Siegfried AGA synthesis step, consisting of two sub-steps A and B was investigated by applying a model based approach. Deepening the process understanding was achieved through performed experiments, which also led to the generation of valuable knowledge for future improvements. A kinetic model consisting of 12 reactions and 15 components was successfully established. The model predicts the effects of changes in process parameters on quality. On this basis recommendations for process optimizations have been formulated.11 - Studentische ArbeitPublikation Triphenylphosphanoxid Reduktion mit Silanen(Hochschule für Life Sciences FHNW, 2022) Brodmann, Nico; Zogg, Andreas; Zogg, Andreas; DSMTriphenylphosphan (TPP) ist ein häufig genutztes Reagenz bei der Wittig-Reaktion. Dabei wird es stöchiometrisch zu Triphenylphosphanoxid (TPPO) umgewandelt, welches zum heutigen Zeitpunkt entsorgt werden muss. Eine Rückführung zu TPP ist für die Industrie von grossem Nutzen. Deshalb wurde eine Reduktion mit Silanen für eine Implementierung untersucht. Es war möglich die grössten Hindernisse dieses Vorgehens für einen Prozess zu umgehen oder zu lösen. So wurde in diesem Zusammenhang die Aufarbeitung komplett neu entworfen und alle Abfallströme für eine Rückführung bzw. Weiterverarbeitung optimiert. Zudem konnten alle Reaktionsparameter und deren Einfluss quantifiziert und verbessert werden.11 - Studentische ArbeitPublikation New Scale-Up Technologies for Hydrogenation Reactions in Multipurpose Pharmaceutical Production Plants(Hochschule für Life Sciences FHNW, 2022) Zogg, Andreas; Furrer, Thierry05 - Forschungs- oder Arbeitsbericht