Institut für Medizintechnik und Medizininformatik
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- Publikation3D Printing and Medical Applications - an Overview(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Revolution or Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D Printing in Medicine: Yesterday – Today - Tomorrow(06/2016) Schumacher, Ralf06 - Präsentation
- Publikation06 - Präsentation
- Publikation3D Visualization of intraoperative stimulation test results for better target selection in DBS surgery (U-PP-04)(2016) Shah, Ashesh; Alonso, Fabiola; Pison, Daniela; Lemaire, Jean-Jaques; Wårdell, Karin; Coste, Jérôme; Schkommodau, Erik; Hemm-Ode, Simone06 - Präsentation
- Publikation3D-Druck in der Medizintechnik – Revolution, Evolution oder Illusion?(2016) Schumacher, Ralf06 - Präsentation
- Publikation3D-Druck und neue Geschäftsmodelle in der Medizintechnik(2015) Schumacher, Ralf06 - Präsentation
- Publikation3D-Druck wird Chirurgen die Operationen erleichtern(Swiss Professional Media, 04/2015) Schumacher, Ralf [in: Technische Rundschau]01B - Beitrag in Magazin oder Zeitung
- Publikation3D-printed auxetic structures for bio-medical application(2018) Schuler, Felix; Renaud, Pascal; de Wild, Michael [in: Swiss Society for Biomaterials and Regenerative Medicine]04 - Beitrag Sammelband oder Konferenzschrift
- Publikation3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine(Elsevier, 2023) Lee, Seunghun S.; Du, Xiaoyu; Smit, Thijs; Bissacco, Elisa G.; Seiler, Daniel; de Wild, Michael; Ferguson, Stephen J. [in: Biomaterials Advances]Despite the recent advances in 3D-printing, it is often difficult to fabricate implants that optimally fit a defect size or shape. There are some approaches to resolve this issue, such as patient-specific implant/scaffold designs based on CT images of the patients, however, this process is labor-intensive and costly. Especially in developing countries, affordable treatment options are required, while still not excluding these patient groups from potential material and manufacturing advances. Here, a selective laser melting (SLM) 3D-printing strategy was used to fabricate a hierarchical, LEGO®-inspired Assemblable Titanium Scaffold (ATS) system, which can be manually assembled in any shape or size with ease. A surgeon can quickly create a scaffold that would fit to the defect right before the implantation during the surgery. Additionally, the direct inclusion of micro- and macroporous structures via 3D-printing, as well as a double acid-etched surface treatment (ST) in the ATS, ensure biocompatibility, sufficient nutrient flow, cell migration and enhanced osteogenesis. Three different structures were designed (non-porous:NP, semi-porous:SP, ultra-porous:UP), 3D-printed with the SLM technique and then surface treated for the ST groups. After analyzing characteristics of the ATS such as printing quality, surface roughness and interconnected porosity, mechanical testing and finite element analysis (FEA) demonstrated that individual and stacked ATS have sufficient mechanical properties to withstand loading in a physiological system. All ATS showed high cell viability, and the SP and UP groups demonstrated enhanced cell proliferation rates compared to the NP group. Furthermore, we also verified that cells were well-attached and spread on the porous structures and successful cell migration between the ATS units was seen in the case of assemblies. The UP and SP groups exhibited higher calcium deposition and RT-qPCR proved higher osteogenic gene expression compared to NP group. Finally, we demonstrate a number of possible medical applications that reveal the potential of the ATS through assembly. © 2023 The Authors01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA baseline wander tracking system for artifact rejection in long-term electrocardiography(IEEE, 2016) Niederhauser, Thomas; Marisa, Thanks; Kohler, Lukas; Haeberlin, Andreas; Wildhaber, Reto; Abächerli, Roger; Goette, Josef; Jacomet, Marcel; Vogel, Rolf [in: IEEE Transactions on Biomedical Circuits and Systems]Long-term electrocardiogram (ECG) signals might suffer from relevant baseline disturbances during physical activity. Motion artifacts in particular are more pronounced with dry surface or esophageal electrodes which are dedicated to prolonged ECG recording. In this paper we present a method called baseline wander tracking (BWT) that tracks and rejects strong baseline disturbances and avoids concurrent saturation of the analog front-end. The proposed algorithm shifts the baseline level of the ECG signal to the middle of the dynamic input range. Due to the fast offset shifts, that produce much steeper signal portions than the normal ECG waves, the true ECG signal can be reconstructed offline and filtered using computationally intensive algorithms. Based on Monte Carlo simulations we observed reconstruction errors mainly caused by the non-linearity inaccuracies of the DAC. However, the signal to error ratio of the BWT is higher compared to an analog front-end featuring a dynamic input ranges above 15 mV if a synthetic ECG signal was used. The BWT is additionally able to suppress (electrode) offset potentials without introducing long transients. Due to its structural simplicity, memory efficiency and the DC coupling capability, the BWT is dedicated to high integration required in long-term and low-power ECG recording systems.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA graphical simulation software for instruction in cardiovascular mechanics physiology(2011) Wildhaber, Reto; Verrey, François; Wenger, Roland H [in: BioMedical Engineering OnLine]Background Computer supported, interactive e-learning systems are widely used in the teaching of physiology. However, the currently available complimentary software tools in the field of the physiology of cardiovascular mechanics have not yet been adapted to the latest systems software. Therefore, a simple-to-use replacement for undergraduate and graduate students' education was needed, including an up-to-date graphical software that is validated and field-tested.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA new approach to 3D-print of fine and complex structures(08/2018) Schuler, Felix06 - Präsentation
- PublikationA new electrospray method for targeted gene delivery(Nature, 03/2018) Boehringer, Stephan; Ruzgys, Paulius; Tamò, Luca; Satkauskas, Saulius; Geiser, Thomas; Gazdhar, Amiq; Hradetzky, David [in: Scientific Reports]A challenge for gene therapy is absence of safe and efficient local delivery of therapeutic genetic material. An efficient and reproducible physical method of electrospray for localized and targeted gene delivery is presented. Electrospray works on the principle of coulombs repulsion, under influence of electric field the liquid carrying genetic material is dispersed into micro droplets and is accelerated towards the targeted tissue, acting as a counter electrode. The accelerated droplets penetrate the targeted cells thus facilitating the transfer of genetic material into the cell. The work described here presents the principle of electrospray for gene delivery, the basic instrument design, and the various optimized parameters to enhance gene transfer in vitro. We estimate a transfection efficiency of up to 60% was achieved. We describe an efficient gene transfer method and a potential electrospray-mediated gene transfer mechanism.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA new model of implant-related osteomyelitis in the metaphysis of rat tibiae(BioMed Central, 08.04.2016) Harrasser, Norbert; Gorkotte, Johannes; Obermeier, Andreas; Feihl, Susanne; Straub, Melanie; Slotta-Huspenina, Julia; von Eisenhart-Rothe, Ruediger; Moser, Walter; Gruner, Philipp; de Wild, Michael; Gollwitzer, Hans; Burgkart, Rainer [in: BMC Musculoskeletal Disorders]Animal models serve as an important tool to understand peri-implant infection. Most of the models use high bacterial loads (>104 colony forming units, CFU) to provide high infection rates. Therefore these animals evolve rather similarly, making comparison between groups and statistical analysis possible. On the other hand, to mimic clinical constellation of surgery-related infections the use of low amounts of bacteria would be more advantageous.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA novel route to molecular self-assembly. Self-intermixed monolayer phases(Wiley, 18.10.2002) de Wild, Michael; Berner, Simon; Suzuki, Hitoshi; Yanagi, Hisao; Schlettwein, Derck; Ivan, Stanislav; Baratoff, Alexis; Guentherodt, Hans-Joachim; Jung, Thomas A. [in: ChemPhysChem]The stars and stripes: A novel route to highly perfect molecular self-assembly is presented. Depending on the relative surface (Ag(111)) coverage of the two species, subphthalocyanine and C60 (green and yellow in the colored STM image) on an surface, well-ordered intermixed monolayers consisting of 1D chains with 1 nm width or 2D hexagonal patterns are formed. The structural parameters and schematic binary "phase diagram" of this system are deduced from detailed room-temperature STM studies. The most important underlying interactions and the relevant properties of the molecules are discussed qualitatively.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationA polyphenol-enriched fraction of rose oil distillation wastewater inhibits cell proliferation, migration and TNF-α-Induced VEGF secretion in human immortalized keratinocytes(Thieme, 2016) Wedler, Jonas; Rusanov, Krasimir; Atanassov, Ivan; Butterweck, Veronika [in: Planta Medica]Water steam distillation of rose flowers separates the essential oil from the polyphenol-containing rose oil distillation wastewater. Recently, a strategy was developed to separate rose oil distillation wastewater into a polyphenol depleted water fraction and a polyphenol-enriched fraction [RF20-(SP-207)]. The objective of the present study was to investigate RF20-(SP-207) and fraction F(IV), augmented in quercetin and ellagic acid, for possible antiproliferative effects in immortalized human keratinocytes (HaCaT) since rose petals are known to contain compounds with potential antiproliferative activity.RF20-(SP-207) revealed dose-dependent antiproliferative activity (IC50 of 9.78 µg/mL). In a nontoxic concentration of 10 µg/mL, this effect was stronger than that of the two positive controls LY294002 (10 µM, PI3 K-inhibitor, 30 % inhibition) and NVP-BEZ235 (100 nM, dual PI3 K/mTOR inhibitor, 30 % inhibition) and clearly exceeded the antiproliferative action of quercetin (50 µM, 25 % inhibition) and ellagic acid (1 µM, 15 % inhibition). Time-lapse microscopy detected a significant impairment of cell migration of RF20-(SP-207) and F(IV). At concentrations of 10 µg/mL of both, extract and fraction, cell migration was strongly suppressed (51 % and 28 % gap closure, respectively, compared to 95 % gap closure 24 hours after control treatment). The suppression of cell migration was comparable to the positive controls LY294002, NVP-BEZ235, and quercetin. Furthermore, basal and TNF-α-stimulated VEGF-secretion was significantly reduced by RF20-(SP-207) and F(IV) at 10 µg/mL (44 % vs. untreated control).In conclusion, RF20-(SP-207) showed promising antiproliferative and antimigratory effects and could be developed as a supportive, therapy against hyperproliferation-involved skin diseases.01A - Beitrag in wissenschaftlicher Zeitschrift